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Open Access Publications from the University of California

Department of Biological Chemistry, UCLA, David Geffen School of Medicine

There are 200 publications in this collection, published between 1995 and 2016.
Other Recent Work (1)

A Folk Remedy for NIDDM: Evidence of Antihyperglycemic Effects of H. Latiflora

Multiple experiments using diabetes animal models have demonstrated the antihyperglycemic properties of several Mexican Copalchi species, mainly Hintonia latiflora (HLA) and Hintonia standleyana (HSL). The active compounds of these plants have recently been characterized and their therapeutic mechanisms proposed. Though widely studied in animals, evidence indicating therapeutic efficacy in patients with non-insulin-dependent diabetes mellitus (NIDDM) is limited. Still, copalchis have been utilized as a folk remedy, and in Germany as a marketed drug, for managing NIDDM. The risks and benefits of using this drug warrant critical analysis. This review summarizes research evidence for the antidiabetic efficacy of Copalchis in NIDDM animal models, recent toxicity findings, and limited clinical findings in human subjects.