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Effects of ICG concentration on the optical properties of erythrocyte-derived nano-vectors

  • Author(s): Tang, J
  • Bahmani, B
  • Burns, J
  • Nuñez, V
  • Mac, J
  • Bacon, D
  • Vullev, V
  • Sun, V
  • Jia, W
  • Nelson, JS
  • Anvari, B
  • et al.
Abstract

© 2015 SPIE. Erythrocyte-based nanoparticle platforms can offer long circulation times not offered by traditional drug delivery methods. We have developed a novel erythrocyte-based nanoparticle doped with indocyanine green (ICG), the only FDA-approved near-infrared chromophore. Here, we report on the absorption and fluorescence emission characteristics of these nanoparticles fabricated using ICG concentrations in the range of 161-323 μM. These nanoparticles may serve as biocompatible optical materials for various clinical imaging and phototherapeutic applications.

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