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Open Access Publications from the University of California

Dynamic epidermal cooling in conjunction with laser treatment of port-wine stains: Theoretical and preliminary clinical evaluations

  • Author(s): Anvari, B
  • Milner, TE
  • Tanenbaum, BS
  • Kimel, S
  • Svaasand, LO
  • Nelson, JS
  • et al.

The clinical objective in laser treatment of port-wine stains (PWS) is to induce selective photothermolysis of subsurface blood vessels without damaging the overlying epidermis. This paper investigates the effectiveness of 'dynamic' cooling, where a cryogen is sprayed on the skin surface for an appropriately short period of time, to eliminate epidermal thermal injury during laser treatment of PWS. Comparative measurements of radiometric surface temperature from cooled and uncooled laser irradiated (585 nm) PWS sites, and theoretical predictions of temperature distributions within skin in response to dynamic cooling in conjunction with laser irradiation are presented. Rapid reduction of skin surface temperature and localization of cooling the epidermis are obtained when a cryogen is sprayed on skin prior to laser irradiation. Successful blanching of the PWS without thermal injury to the overlying epidermis is accomplished. © 1995 W.B. Saunders Company Ltd.

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